Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
نویسندگان
چکیده
منابع مشابه
Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
The notion that breast cancers can survive in an individual patient in a dormant state only to grow as metastatic disease in the future, is in our view incontrovertibly established. Convincing too is the evidence that surgery to remove the primary tumor often terminates dormancy resulting in accelerated relapses. Accepting that many deaths due to breast cancer might be averted were we to unders...
متن کاملBlockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis.
BACKGROUND Nucleoside Diphosphate Kinase (NDPK), described as NM23 a metastasis suppressor, is found in the culture medium of cancer cells lines suggesting that the kinase may have an extracellular role. We propose that extracellular NM23 released from breast cancers in vivo stimulates tumor cell migration, proliferation and endothelial cell angiogenesis in support of metastasis development. ...
متن کاملExpression of the nm23 gene and breast cancer prognosis.
(/) W H D E N PL, PlANTADOSI S, AND THE LUNG CANCER STUDY GROUP: Preoperalive chemotherapy (cisplatin and fluorouracil) and radiation therapy in stage III non-small-cell lung cancer: A phase II study of the Lung Cancer Study Group. JNatl Cancer Inst 83:266-273, 1991 (2) SALMON SE, ED:Adjuvant Therapy of Cancer IV. Philadelphia: Saunders, 1990 (i) ROONEY M, KISH J, JACOBS J, ET AL: Improved comp...
متن کاملEvaluation of Cytotoxicity Activity and NM23 Gene Expression in T47D Breast Cancer Cell Line Treated with Glycyrrhiza glabra Extract
Glycyrrhiza is a genus of about 20 accepted species in the legume family (Fabaceae), with a distribution in Asia, Australia, Europe, and the Americas. Recently, about 30 species from the genus Glycyrrhiza have been found and used in traditional medicine for treating cancer. Different studies confirmed that down regulation of Non-metastatic protein (NM23), a metastasis suppressor gene is related...
متن کاملIntracellular and extracellular microRNAs in breast cancer.
BACKGROUND Successful treatment of breast cancer is enhanced by early detection and, if possible, subsequent patient-tailored therapy. Toward this goal, it is essential to identify and understand the most relevant panels of biomarkers, some of which may also have relevance as therapeutic targets. METHODS We critically reviewed published literature on microRNAs (miRNAs) as relevant to breast c...
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ژورنال
عنوان ژورنال: Cancers
سال: 2011
ISSN: 2072-6694
DOI: 10.3390/cancers3032844